Scientific Publication

In vivo preliminary investigations of the effects of the benzimidazolen anthelmintic drug flubendazole on rat embryos and fetuses

author(s) Longo, M. - Zanoncelli, S. - Messina, M. - Scandale, I. - Mackenzie, C. - Geary, T. - Marsh, K. - Lindley, D. - Mazue, G.
from UK Foreign, Commonwealth & Development Office (FCDO)
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Longo M, Zanoncelli S, Messina M, Scandale I, Mackenzie C, Geary T, Marsh K, Lindley D, Mazué G.(2014) In vivo preliminary investigations of the effects of the benzimidazolen anthelmintic drug flubendazole on rat embryos and fetuses. Reproductive Toxicology Volume 49, November 2014, Pages 33-42 https://doi.org/10.1016/j.reprotox.2014.06.009

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Abstract

Flubendazole, in a new formulation with high systemic bioavailability, has been proposed as a macrofilaricide against filarial diseases. The embryotoxic activity of a new oral flubendazole formulation was investigated. It did not interfere with rat embryofetal development. This research is part of the Drugs for Neglected Diseases initiative (DNDi)

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