Scientific Publication

Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion

author(s) Peacock, T. - Benton, D. - Sadeyen, J. - Chang, P.
from UK Foreign, Commonwealth & Development Office (FCDO)
permalink open
themes
regions
  • South-Eastern Asia
  • Asia
  • World
  • Southern Asia
citation

Peacock T, Benton D, Sadeyen J, Chang P, Sealy J, Bryant J, Martin S, Shelton H, McCauley J, Barclay W, Iqbal M (2017). Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion. Emerging Microbes Infection. 6(3): e11

Publications and datasets provided via GARDIAN

Abstract

H9N2 avian influenza viruses are primarily a disease of poultry; however, they occasionally infect humans and are considered a potential pandemic threat. Little work has been performed to assess the intrinsic biochemical properties related to zoonotic potential of H9N2 viruses. The objective of this study, therefore, was to investigate H9N2 haemagglutinins (HAs) using 2 well-known correlates for human adaption: receptor-binding avidity and pH of fusion This work arises from the Zoonoses and Emerging Livestock Systems (ZELS) programme

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