Scientific Publication

Pharmacodynamic Activity of Dapivirine and Maraviroc Single Entity and Combination Topical Gels for HIV-1 Prevention

author(s) Dezzutti, C.S.. - Rohan, L.C.. - Nuttall, J.. - Devlin, B.. - Brown, E.R.. - Lin Wang, Moncla. - B., Teeple. - E.A., Yandura.
from UK Foreign, Commonwealth & Development Office (FCDO)
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Dezzutti, C.S.; Yandura, S.; Lin Wang; Moncla, B.; Teeple, E.A.; Devlin, B.; Nuttall, J.; Brown, E.R.; Rohan, L.C. Pharmacodynamic Activity of Dapivirine and Maraviroc Single Entity and Combination Topical Gels for HIV-1 Prevention. Pharmaceutical Research (2015) 32 (11) 3768-3781. (DOI: 10.1007/s11095-015-1738-7)

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Abstract

Dapivirine (DPV), a non-nucleoside reverse transcriptase inhibitor, and maraviroc (MVC), a CCR5 antagonist, were formulated into aqueous gels designed to prevent mucosal HIV transmission

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