Classical swine fever Virus: Viral proteins as virulent factors

Abstract

Classical swine fever virus is the eminently infectious viral disease of pigs and has wide ranging all over the world. It causes severe economic harm to the entire pig industry globally. The CSFV genome encodes a single large polypeptide which undergoes co- and post-translational modifications to produce four structural (C, Erns, E1, E2) and eight non-structural proteins (Npro, p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B). The CSFV viral proteins are the main virulent factors and involved in virus adsorption, induction of protective immunity, virus spreading, virus-host interactions, gene regulation and expression and pathogenesis. CSFV viral proteins can be used to develop recombinant vaccines against CSFV. In this review, the current knowledge regarding the role of both structural and non-structural glycoproteins are responsible for the CSFV virulence is discussed